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KMID : 0882420130840020203
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Korean Journal of Medicine
2013 Volume.84 No. 2 p.203 ~ p.210
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Clinical and Serological Findings in Patients with Toxocariasis in the Pohang Region: The Features of Toxocariasis in Pohang
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Ryu Byung-Han
Park Jun-Seok
Jung Yeo-Jin
Kang Soo-Kyoung
Lee Seung-Hee
Choi Sung-Jin
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Abstract
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Background/Aims: This study was performed to investigate the clinical and serological characteristics of toxocariasis in the Pohang region.
Methods: A total of 145 patients with peripheral eosinophilia (> 450 cells/μL) were enrolled and divided into two groups based on Toxocara excretory-secretory IgG enzyme-linked immunosorbent assay (ELISA) positivity, and the clinical features and serologic markers were compared between the two groups.
Results: The seropositive rate of Toxocara was 62.1%. The serum total eosinophils (p = 0.038), total IgE level (p < 0.01), Dermatophagoides farinae (Df) seropositivity rate (p < 0.01), frequency of eosinophilic tissue infiltration in the lung or liver (p < 0.01), and ingestion of raw cow meat or liver (p < 0.01) were higher in seropositive patients than in seronegative patients. However, the presence of asthma and rhinitis (p < 0.01) were more frequent in seronegative patients. Among seropositive patients, positive correlations were observed between serum total IgE, total eosinophils, and the optical density value of the Toxocara IgG ELISA (p < 0.01; p = 0.015, respectively). The specific IgE to Df was significantly higher (p < 0.01) than that to Dermatophagoides pteronyssinus (Dp), suggesting a cross reaction between the Df antigen and the Toxocara antigen.
Conclusions: Patients who have elevated serum total IgE and have eosinophilia without allergic disease might have toxocariasis. The lower frequency of asthma or rhinitis and a tendency for higher specific IgE to Df than that to Dp could be useful findings for the diagnosis of toxocariasis in patients with eosinophilia.
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KEYWORD
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Toxocariasis, Toxocara canis, Eosinophilia, Immunoglobulin E, Dermatophagoides
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